DELFICTUS IO — REPORTS

Med Chem

Reports

A PRISM-4D run against a single target produces a complete medicinal-chemistry-ready dossier. Each report includes the ranked binding-site list with persistence, lining-residue maps, and accessibility profile; per-site pocket chemistry, anchor points, and growth vectors for library design; pharmacophore features and replicate consensus across N runs; and a freeze attestation with SHA-256-anchored manifest for end-to-end reproducibility. The dossiers below were produced by the same engine that can be run live against any of the B01–B10 preprint-validated targets.

Available reports
Featured Dossier
MYC–MAX (1NKP) — PPI-interface cryptic-site analysis
Twenty-five lining residues across the MYC–MAX bHLH-LZ heterodimer interface, scored under the strict-SR / null-control / PFR validation stack. Sub-five-minute single-GPU runtime, with the full provenance manifest and freeze attestation embedded in the dossier.
PDB · 1NKP 25 lining residues < 5 min single-GPU
Open dossier →
0.483Strict SR@1 (panel)
12.2×PFR null enrichment
p ≤ 0.001Null separation
PRISM-4D preprint cover page
Preprint · bioRxiv MS BIORXIV/2026/725676
PRISM-4D — Prospective-Retrospective Validation
Spike-event-driven nonequilibrium molecular sensing for cryptic binding-site discovery. Strict SR@1 = 0.483 against fpocket 0.224 and P2Rank 0.382 on a 9-target prediction-locked blind panel; 12.2× PFR null enrichment over a temporal-scramble baseline.
Read preprint (PDF) →
Community · Voting
Direct the next public case study
Eight prospective targets where physics-driven analysis offers something static-structure methods don't. Cast an unofficial vote on which target PRISM-4D analyzes next, or propose one of your own.
Open voting page →
— Try it

Run a target end-to-end, or try the zero-shot cryptic-site predictor.

Execute the live PRISM-4D engine against any of the B01–B10 preprint-validated targets with logs streaming back in real time, or exercise the PRISM-AI zero-shot cryptic-site predictor while the closed-loop infrastructure is in development.

Run the live engine Try zero-shot cryptic-site predictor in dev